DNMT3B antibody (AA 1-150)
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- Target See all DNMT3B Antibodies
- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
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Binding Specificity
- AA 1-150
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This DNMT3B antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
- Purpose
- DNMT3B Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human DNMT3B (AA: 1-150) expressed in E. Coli.
- Clone
- 7E5E9C1
- Isotype
- IgG1
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
- Alternative Name
- DNMT3B (DNMT3B Products)
- Synonyms
- DNMT3B antibody, LOC100218113 antibody, ICF antibody, ICF1 antibody, M.HsaIIIB antibody, MmuIIIB antibody, cb91 antibody, dnmt3bl antibody, dnmt7 antibody, sb:cb91 antibody, wu:fb16h07 antibody, DNA methyltransferase 3 beta antibody, DNA methyltransferase 3B antibody, DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a antibody, DNMT3B antibody, Dnmt3b antibody, dnmt3b antibody, dnmt3ba antibody
- Background
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Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Aliases: ICF, ICF1, M.HsaIIIB
- Molecular Weight
- 95.8kDa
- Gene ID
- 1789
- HGNC
- 1789
- UniProt
- Q9UBC3
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