DNMT3B antibody (AA 1-150)

Catalog No. ABIN5542517

Product Details anti-DNMT3B Antibody

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Binding Specificity: AA 1-150

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DNMT3B antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: DNMT3B Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human DNMT3B (AA: 1-150) expressed in E. Coli.

Clone: 4D1A2E5

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for DNMT3B

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Alternative Name: DNMT3B (DNMT3B Products)

Synonyms: DNMT3B antibody, LOC100218113 antibody, ICF antibody, ICF1 antibody, M.HsaIIIB antibody, MmuIIIB antibody, cb91 antibody, dnmt3bl antibody, dnmt7 antibody, sb:cb91 antibody, wu:fb16h07 antibody, DNA methyltransferase 3 beta antibody, DNA methyltransferase 3B antibody, DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a antibody, DNMT3B antibody, Dnmt3b antibody, dnmt3b antibody, dnmt3ba antibody

Background:

Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Aliases: ICF, ICF1, M.HsaIIIB

Molecular Weight: 95.8kDa

Gene ID: 1789

HGNC: 1789

UniProt: Q9UBC3