TRAF2 antibody (AA 39-188)

Catalog No. ABIN5542488

Product Details anti-TRAF2 Antibody

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Binding Specificity: AA 39-188

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRAF2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: TRAF2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TRAF2 (AA: 39-188) expressed in E. Coli.

Clone: 5C2C3

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TRAF2

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Alternative Name: TRAF2 (TRAF2 Products)

Synonyms: MGC:45012 antibody, TRAP antibody, TRAP3 antibody, TANK antibody, AI325259 antibody, TNF-receptor-associated factor 2 antibody, conjugal transfer protein TraF antibody, TNF receptor associated factor 2 antibody, TNF receptor-associated factor 2 antibody, Tnf receptor-associated factor 2 antibody, LOC661716 antibody, traF2 antibody, TRAF2 antibody, Traf2 antibody

Background:

Description: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Aliases: TRAP, TRAP3, MGC:45012

Molecular Weight: 55.8KD

Gene ID: 7186

HGNC: 7186

UniProt: Q12933

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins