RAP1GAP antibody (AA 412-660)

Catalog No. ABIN5542476

Product Details anti-RAP1GAP Antibody

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Binding Specificity: AA 412-660

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAP1GAP antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: RAP1GAP Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human RAP1GAP (AA: 412-660) expressed in E. Coli.

Clone: 2G7B6

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for RAP1GAP

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Alternative Name: RAP1GAP (RAP1GAP Products)

Synonyms: RAP1GA1 antibody, RAP1GAP1 antibody, RAP1GAPII antibody, RAPGAP antibody, 1300019I11Rik antibody, 2310004O14Rik antibody, AI427470 antibody, Rap1ga1 antibody, RAP1 antibody, RAP1GAP antibody, rap1ga1 antibody, rap1gap1 antibody, rap1gapii antibody, rapgap antibody, zgc:175180 antibody, DKFZp459A114 antibody, RAP1 GTPase activating protein antibody, Rap1 GTPase-activating protein antibody, RAP1 GTPase activating protein 1 antibody, RAP1 GTPase activating protein L homeolog antibody, Rap1 GTPase-activating protein 1 antibody, si:dkey-166d12.2 antibody, RAP1GAP antibody, Rap1gap antibody, RAP1GAP1 antibody, rap1gap.L antibody, Tsp_09520 antibody, rap1gap antibody, si:dkey-166d12.2 antibody

Background:

Description: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Aliases: RAPGAP, RAP1GA1, RAP1GAP1, RAP1GAPII

Molecular Weight: 73.4kDa

Gene ID: 5909

HGNC: 5909

UniProt: P47736