CBX3 antibody (AA 1-183)

Catalog No. ABIN5542474

Product Details anti-CBX3 Antibody

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Binding Specificity: AA 1-183

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBX3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Purpose: CBX3 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CBX3 (AA: 1-183) expressed in E. Coli.

Clone: 6D1C4

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for CBX3

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Alternative Name: CBX3 (CBX3 Products)

Synonyms: HECH antibody, HP1-GAMMA antibody, HP1Hs-gamma antibody, Hp1-gamma antibody, HP1g antibody, M32 antibody, cbx3 antibody, cbx3a antibody, xhp1g antibody, wu:fb61b02 antibody, zgc:153397 antibody, chromobox 3 antibody, chromobox 3 L homeolog antibody, chromobox protein homolog 3 pseudogene antibody, chromobox homolog 3a (HP1 gamma homolog, Drosophila) antibody, CBX3 antibody, Cbx3 antibody, cbx3.L antibody, LOC100355282 antibody, cbx3a antibody

Background:

Description: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

Aliases: HECH, HP1-GAMMA, HP1Hs-gamma

Molecular Weight: 20.8kDa

Gene ID: 11335

HGNC: 11335

UniProt: Q13185