TCF4 antibody (AA 518-667)

Catalog No. ABIN5542393

Product Details anti-TCF4 Antibody

Target: TCF4 (Transcription Factor 4 (TCF4))

Binding Specificity: AA 518-667

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TCF4 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: TCF4 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TCF4 (AA: 518-667) expressed in E. Coli.

Clone: 7B1B3

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TCF4

Target: TCF4 (Transcription Factor 4 (TCF4))

Alternative Name: TCF4 (TCF4 Products)

Synonyms: E2-2 antibody, ITF-2 antibody, ITF2 antibody, PTHS antibody, SEF-2 antibody, SEF2 antibody, SEF2-1 antibody, SEF2-1A antibody, SEF2-1B antibody, TCF-4 antibody, bHLHb19 antibody, 5730422P05Rik antibody, ASP-I2 antibody, E2.2 antibody, ITF-2b antibody, ME2 antibody, MITF-2A antibody, MITF-2B antibody, TFE antibody, Tcf-4 antibody, TCF7L2 antibody, XE2 antibody, Xtcf-4 antibody, Xtcf4 antibody, e2-A antibody, tcf-4 antibody, transcription factor 4 antibody, transcription factor 4 S homeolog antibody, TCF4 antibody, Tcf4 antibody, tcf4 antibody, tcf4.S antibody

Background:

Description: This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.

Aliases: E2-2, ITF2, PTHS, SEF2, FECD3, ITF-2, SEF-2, TCF-4

Molecular Weight: 71.3kDa

Gene ID: 6925

HGNC: 55818

UniProt: P15884

Pathways: WNT Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus