TTR antibody (AA 1-147)

Catalog No. ABIN5542369

Product Details anti-TTR Antibody

Target: TTR (Transthyretin (TTR))

Binding Specificity: AA 1-147

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TTR antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: TTR Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TTR (AA: 1-147) expressed in E. Coli.

Clone: 2E10C5

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: TTR (TTR Products)

Background:

Description: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein, it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported, most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

Aliases: CTS, CTS1, PALB, TBPA, HEL111, HsT2651

Molecular Weight: 15.9kDa

Gene ID: 7276

HGNC: 7276

UniProt: P02766

Pathways: Hormone Transport