Phospholipase C gamma 2 antibody (AA 826-985)

Catalog No. ABIN5542311

Product Details anti-Phospholipase C gamma 2 Antibody

Target: Phospholipase C gamma 2 (PLCG2)

Binding Specificity: AA 826-985

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Phospholipase C gamma 2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Purpose: PLCG2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PLCG2 (AA: 826-985) expressed in E. Coli.

Clone: 1E10C11

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Phospholipase C gamma 2

Target: Phospholipase C gamma 2 (PLCG2)

Alternative Name: PLCG2 (PLCG2 Products)

Synonyms: PLCgamma2 antibody, Plcg-2 antibody, APLAID antibody, FCAS3 antibody, phospholipase C, gamma 2 antibody, phospholipase C gamma 2 antibody, phospholipase C, gamma 2 (phosphatidylinositol-specific) antibody, Plcg2 antibody, PLCG2 antibody

Background:

Description: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Aliases: FCAS3, APLAID, PLC-IV, PLC-gamma-2

Molecular Weight: 147.9kDa

Gene ID: 5336

HGNC: 5336

UniProt: P16885

Pathways: RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling