BIN1 antibody (AA 189-398)
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- Target See all BIN1 Antibodies
- BIN1 (Bridging Integrator 1 (BIN1))
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Binding Specificity
- AA 189-398
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This BIN1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Purpose
- BIN1 Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human BIN1 (AA: 189-398) expressed in E. Coli.
- Clone
- 3B6A4
- Isotype
- IgG2b
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- BIN1 (Bridging Integrator 1 (BIN1))
- Alternative Name
- BIN1 (BIN1 Products)
- Background
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Description: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Aliases: AMPH2, AMPHL, SH3P9
- Molecular Weight
- 64.7kDa
- Gene ID
- 274
- HGNC
- 274
- UniProt
- O00499
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