NMDA 1 Receptor antibody (pSer890)

Catalog No. ABIN5540835

Product Details anti-NMDA 1 Receptor Antibody

Target: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Binding Specificity: pSer890

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMDA 1 Receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.

Purification: Affinity chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1 (KLH-conjugated)

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 1:50~1:100. Immunofluorescence: 1:100~1:200.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for NMDA 1 Receptor

Target: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Alternative Name: nmda receptor 1 (NMDA R1 Products)

Synonyms: CG2902 antibody, DMNMDAR1 antibody, DNMDAR-I antibody, DNmdar antibody, DmelNmdar1 antibody, Dmel\\CG2902 antibody, DrNR1 antibody, NMDA antibody, NMDA R1 antibody, NMDAR1 antibody, NMdar1 antibody, NR1 antibody, NRI antibody, Nmdar antibody, dNR1 antibody, dnmdar-I antibody, nmr antibody, NMDA receptor 1 antibody, Nmdar1 antibody

Background: NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

UniProt: Q05586