PTPRT antibody (AA 1-742)

Catalog No. ABIN5540588

Product Details anti-PTPRT Antibody

Target: PTPRT (Receptor Protein Tyrosine Phosphatase (PTPRT))

Binding Specificity: AA 1-742

Reactivity: Human, Rat, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTPRT antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: Monoclonal antibodies 3G4 and 3D7 have been directed against the extracellular domain of RPTPμ.

Purification: Purified

Immunogen: This antibody has been derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPmu molecule (aa 1-742), fused COOH terminally to GST.

Clone: 3D7

Isotype: IgG2a

Application Details

Application Notes: Western blot. Immunoprecipitation. Immunofluorescence. Flow Cytometry.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PTPRT

Target: PTPRT (Receptor Protein Tyrosine Phosphatase (PTPRT))

Alternative Name: ptprt (PTPRT Products)

Background: Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substrates. RPTPμ is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPμ consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPμ is catalytically active, whereas its second (C-terminal) domain is inactive. RPTPμ is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.

UniProt: O14522