KCNK2 antibody (AA 4-14)

Catalog No. ABIN5540445

Product Details anti-KCNK2 Antibody

Target: KCNK2 (Potassium Channel, Subfamily K, Member 2 (KCNK2))

Binding Specificity: AA 4-14

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: SASRERPGYT A

Specificity: This antibody reacts with the 47 kDa TREK-1 in Jurkat cell extract.

Purification: Protein G affinity

Immunogen: A synthetic peptide derived from the amino sequence 4-14 of human TREK-1, conjugated with KLH

Application Details

Application Notes: ELISA: The antibody (1:500,000 diluted) can detect the TREK-1 peptide coated on ELISA plate at 100 ng/well. Western blot: Dilute approx. 1:3,000 to detect the 47 kDa TREK-1 in Jurkat cell extract.

Restrictions: For Research Use only

Handling

Buffer: 0.01M PBS, pH 7.4

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for KCNK2

Target: KCNK2 (Potassium Channel, Subfamily K, Member 2 (KCNK2))

Alternative Name: kcnk2 (KCNK2 Products)

Synonyms: KCNK2 antibody, K2p2.1 antibody, TPKC1 antibody, TREK antibody, TREK-1 antibody, TREK1 antibody, hTREK-1c antibody, hTREK-1e antibody, A430027H14Rik antibody, AI848635 antibody, Trek-1 antibody, rTREK1d antibody, potassium two pore domain channel subfamily K member 2 antibody, potassium channel, two pore domain subfamily K, member 2 antibody, potassium channel, subfamily K, member 2 antibody, KCNK2 antibody, kcnk2 antibody, Kcnk2 antibody

Background: TWIK-related potassium channel 1(TREK-1), also known as K2P2.1, is a two pore domain gated potassium channel that is involved with pain reception. TREK-1 is highly expressed in small sensory neurons and is extensively colocalized with TRPV1. TREK-1 is sensitive to noxious stimuli including extracellular pH , temperature, mechanical force, osmotic pressure and other stimuli. TREK-1 is one of the targets for pain mediator and anaesthesia drug.