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WDR48 antibody (C-Term)

WDR48 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5538309
  • Target See all WDR48 Antibodies
    WDR48 (WD Repeat Domain 48 (WDR48))
    Binding Specificity
    • 10
    • 9
    • 7
    • 1
    AA 603-630, C-Term
    Reactivity
    • 20
    • 4
    • 3
    Human
    Host
    • 21
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    This WDR48 antibody is un-conjugated
    Application
    • 19
    • 17
    • 14
    • 13
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product WDR48 Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100

    For FACS starting dilution is: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.4 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    WDR48 (WD Repeat Domain 48 (WDR48))
    Alternative Name
    WDR48 (WDR48 Products)
    Synonyms
    P80 antibody, UAF1 antibody, 8430408H12Rik antibody, mKIAA1449 antibody, WD repeat domain 48 antibody, WDR48 antibody, Wdr48 antibody
    Background
    Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
    Molecular Weight
    76 kDa
    Gene ID
    57599
    UniProt
    Q8TAF3
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