SRSF2 antibody (AA 76-105)

Catalog No. ABIN5537524

Product Details anti-SRSF2 Antibody

Target: SRSF2 (serine/arginine-Rich Splicing Factor 2 (SRSF2))

Binding Specificity: AA 76-105

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRSF2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This SFRS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human SFRS2.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SRSF2

Target: SRSF2 (serine/arginine-Rich Splicing Factor 2 (SRSF2))

Alternative Name: SFRS2 (SRSF2 Products)

Synonyms: PR264 antibody, SC-35 antibody, SC35 antibody, SFRS2 antibody, SFRS2A antibody, SRp30b antibody, D11Wsu175e antibody, MRF-1 antibody, Pr264 antibody, Sfrs10 antibody, Sfrs2 antibody, pr264 antibody, sc-35 antibody, sc35 antibody, sfrs2 antibody, sfrs2a antibody, srp30b antibody, serine and arginine rich splicing factor 2 antibody, serine/arginine-rich splicing factor 2 antibody, serine/arginine-rich splicing factor 2 L homeolog antibody, SRSF2 antibody, Srsf2 antibody, srsf2.L antibody

Background: SFRS2 is necessary for the splicing of pre-mRNA. The protein is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. And it interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. It binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3' and can bind to beta-globin mRNA and commit it to the splicing pathway.

Molecular Weight: 25 kDa

Gene ID: 6427

UniProt: Q01130