STK3 antibody (C-Term)
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- Target See all STK3 Antibodies
- STK3 (serine/threonine Kinase 3 (STK3))
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Binding Specificity
- AA 387-415, C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This STK3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This Mouse Stk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of mouse Stk3.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product STK3 Primary Antibody
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- Application Notes
- For WB starting dilution is: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- STK3 (serine/threonine Kinase 3 (STK3))
- Alternative Name
- Stk3 (STK3 Products)
- Synonyms
- KRS1 antibody, MST2 antibody, 0610042I06Rik antibody, MST antibody, Mst2 antibody, Mst3 antibody, Ste20 antibody, mess1 antibody, mst2 antibody, xstk3 antibody, wu:fc19e11 antibody, zgc:55383 antibody, serine/threonine kinase 3 antibody, serine/threonine kinase 3 S homeolog antibody, serine/threonine kinase 3 (STE20 homolog, yeast) antibody, STK3 antibody, Stk3 antibody, stk3.S antibody, stk3 antibody
- Background
- Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.
- Molecular Weight
- 57 kDa
- Gene ID
- 56274
- UniProt
- Q9JI10
- Pathways
- Tube Formation
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