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ADRA2B antibody (AA 343-369)

ADRA2B Reactivity: Human WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5532815
  • Target See all ADRA2B Antibodies
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Binding Specificity
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 343-369
    Reactivity
    • 22
    • 5
    • 4
    Human
    Host
    • 22
    • 2
    • 1
    Rabbit
    Clonality
    • 23
    • 2
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADRA2B antibody is un-conjugated
    Application
    • 16
    • 9
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ADRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-369 amino acids from the Central region of human ADRA2B.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ADRA2B Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100

    For FACS starting dilution is: 1:10~50

    For IF starting dilution is: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Alternative Name
    ADRA2B (ADRA2B Products)
    Synonyms
    ADRA2L1 antibody, ADRA2RL1 antibody, ADRARL1 antibody, ALPHA2BAR antibody, alpha-2BAR antibody, Adra-2b antibody, [a]2B antibody, alpha2-C2 antibody, alpha2B antibody, ADRA2B antibody, zgc:194747 antibody, Adra2b antibody, adrenoceptor alpha 2B antibody, adrenergic receptor, alpha 2b antibody, adrenergic, alpha-2B-, receptor antibody, adrenoceptor alpha 2C antibody, ADRA2B antibody, Adra2b antibody, ADRA2C antibody, adra2b antibody
    Background
    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
    Molecular Weight
    50 kDa
    Gene ID
    151
    UniProt
    P18089
    Pathways
    EGFR Signaling Pathway, cAMP Metabolic Process
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