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PRDM6 antibody (N-Term)

PRDM6 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5531881
  • Target See all PRDM6 Antibodies
    PRDM6 (PR Domain Containing 6 (PRDM6))
    Binding Specificity
    • 9
    • 8
    • 6
    • 2
    • 1
    • 1
    AA 44-72, N-Term
    Reactivity
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 22
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This PRDM6 antibody is un-conjugated
    Application
    • 22
    • 13
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6.
    Isotype
    Ig Fraction
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    Discover our top product PRDM6 Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.35 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    PRDM6 (PR Domain Containing 6 (PRDM6))
    Alternative Name
    PRDM6 (PRDM6 Products)
    Synonyms
    Gm92 antibody, PRISM antibody, RGD1559594 antibody, PRDM6 antibody, PR/SET domain 6 antibody, PR domain containing 6 antibody, putative histone-lysine N-methyltransferase PRDM6 antibody, PRDM6 antibody, Prdm6 antibody, LOC100354345 antibody, prdm6 antibody
    Background
    Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).
    Molecular Weight
    64 kDa
    Gene ID
    93166
    UniProt
    Q9NQX0
    Pathways
    Regulation of Muscle Cell Differentiation
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