PRDM6 antibody (N-Term)

Catalog No. ABIN5531881

Product Details anti-PRDM6 Antibody

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Binding Specificity: AA 44-72, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM6 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.35 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PRDM6

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Alternative Name: PRDM6 (PRDM6 Products)

Synonyms: Gm92 antibody, PRISM antibody, RGD1559594 antibody, PRDM6 antibody, PR/SET domain 6 antibody, PR domain containing 6 antibody, putative histone-lysine N-methyltransferase PRDM6 antibody, PRDM6 antibody, Prdm6 antibody, LOC100354345 antibody, prdm6 antibody

Background: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).

Molecular Weight: 64 kDa

Gene ID: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation