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GCAP1 antibody (C-Term)

GUCA1A Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5531246
  • Target See all GCAP1 (GUCA1A) Antibodies
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Binding Specificity
    • 15
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    AA 160-191, C-Term
    Reactivity
    • 20
    • 18
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 34
    • 1
    Rabbit
    Clonality
    • 34
    • 1
    Polyclonal
    Conjugate
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GCAP1 antibody is un-conjugated
    Application
    • 29
    • 17
    • 13
    • 13
    • 10
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogen
    This GCAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GUCA1A Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Alternative Name
    GCAP1 (GUCA1A Products)
    Synonyms
    C6orf131 antibody, COD3 antibody, CORD14 antibody, GCAP antibody, GCAP1 antibody, GUCA antibody, GUCA1 antibody, dJ139D8.6 antibody, MGC84170 antibody, GUCA1A antibody, guca1a antibody, MGC146317 antibody, GC-A antibody, Gcap1 antibody, Guca1 antibody, mGCAP1 antibody, gcap1 antibody, guanylate cyclase activator 1A antibody, guanylate cyclase activator 1A L homeolog antibody, guanylate cyclase activator 1A (retina) antibody, guanylate cyclase activator 1a (retina) antibody, GUCA1A antibody, Guca1a antibody, guca1a.L antibody, guca1a antibody
    Background
    Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
    Molecular Weight
    23 kDa
    Gene ID
    2978
    UniProt
    P43080
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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