DUSP14 antibody (C-Term)

Catalog No. ABIN5531046

Product Details anti-DUSP14 Antibody

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Binding Specificity: AA 168-198, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This DUSP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the C-terminal region of human DUSP14.

Isotype: Ig Fraction

Application Details

Application Notes: For IHC-P starting dilution is: 1:50~100

For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DUSP14

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Alternative Name: DUSP14 (DUSP14 Products)

Synonyms: MGC84083 antibody, zgc:101746 antibody, DUSP14 antibody, mkp-l antibody, mkp6 antibody, MKP-L antibody, MKP6 antibody, 1110014C10Rik antibody, 2310042C07Rik antibody, D11Ertd395e antibody, Mkp6 antibody, dual specificity phosphatase 14 antibody, dual specificity phosphatase 14 L homeolog antibody, DUSP14 antibody, dusp14.L antibody, dusp14 antibody, Dusp14 antibody

Background: DUSP14 is involved in the inactivation of MAP kinases. This proein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 (CD80) and B7-2 (CD86) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.

Molecular Weight: 22 kDa

Gene ID: 11072

UniProt: O95147