Gastrin-Releasing Peptide antibody (AA 123-152)

Catalog No. ABIN5530774

Product Details anti-Gastrin-Releasing Peptide Antibody

Target: Gastrin-Releasing Peptide (GRP)

Binding Specificity: AA 123-152

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gastrin-Releasing Peptide antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.47 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Gastrin-Releasing Peptide

Target: Gastrin-Releasing Peptide (GRP)

Alternative Name: GRP (GRP Products)

Synonyms: BLP antibody, GRP antibody, BN antibody, GRP-10 antibody, preproGRP antibody, proGRP antibody, gastrin releasing peptide antibody, Grp antibody, GRP antibody

Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

Molecular Weight: 43 kDa

Gene ID: 2925

UniProt: P30550

Pathways: Peptide Hormone Metabolism, Hormone Activity