Neurocan antibody

Catalog No. ABIN5519042

Product Details anti-Neurocan Antibody

Target: Neurocan (NCAN)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurocan antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Neurocan detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: HENTWIGLND RIVERDFQWT DNTGLQFENW RENQPDNFFA

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Neurocan detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: neurocan
Protein Name: Neurocan core protein

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence of human Neurocan (HENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFA).

Isotype: IgG

Application Details

Application Notes: Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-Neurocan antibody (ABIN5519042)

Wang, Zhang, Zhang, Fan, Shen, Hu, Chen: "Oxygen-glucose deprivation induced glial scar-like change in astrocytes." in: PLoS ONE, Vol. 7, Issue 5, pp. e37574, (2012) (PubMed).

Target Details for Neurocan

Target: Neurocan (NCAN)

Alternative Name: NCAN (NCAN Products)

Synonyms: cspg3 antibody, ncan antibody, si:ch211-123b7.1 antibody, NCAN antibody, CSPG3 antibody, Cspg3 antibody, C230035B04 antibody, Cspg3-rs antibody, Tgfbit antibody, neurocan b antibody, neurocan antibody, ncanb antibody, NCAN antibody, Ncan antibody

Background: Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.

Synonyms: Neurocan core protein, Chondroitin sulfate proteoglycan 3, NCAN, CSPG3, NEUR

Gene ID: 1463

UniProt: O14594

Pathways: Glycosaminoglycan Metabolic Process