ECE1 antibody (AA 18-233)

Catalog No. ABIN5518828

Product Details anti-ECE1 Antibody

Target: ECE1 (Endothelin-Converting Enzyme 1 (ECE1))

Binding Specificity: AA 18-233

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ECE1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Endothelin-converting enzyme 1(ECE1) detection. Tested with WB in Human,Mouse,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Endothelin-converting enzyme 1(ECE1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: endothelin converting enzyme 1
Protein Name: Endothelin-converting enzyme 1

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ECE1 recombinant protein (Position: M18-T233). Human ECE1 shares 94% and 93.5% amino acid (aa) sequence identity with mouse and rat ECE1, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-ECE1 antibody (ABIN5518828)

Liu, Zhu, Zhou, Wei, Long, Chen, Ling, Ge, Zhuo: "Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells." in: Cell stress & chaperones, Vol. 19, Issue 6, pp. 827-35, (2014) (PubMed).

Target Details for ECE1

Target: ECE1 (Endothelin-Converting Enzyme 1 (ECE1))

Alternative Name: ECE1 (ECE1 Products)

Synonyms: ECE antibody, Ece antibody, AW322500 antibody, ECE-1 antibody, ECE-1a antibody, ECE-1b antibody, ECE-1d antibody, ece1 antibody, MGC52874 antibody, MGC130791 antibody, fd11b07 antibody, wu:fd11b07 antibody, zgc:154079 antibody, endothelin converting enzyme 1 antibody, endothelin converting enzyme like 1 antibody, endothelin converting enzyme 1 L homeolog antibody, endothelin-converting enzyme 1 antibody, Endothelin-converting enzyme 1 antibody, ECE1 antibody, ECEL1 antibody, Ece1 antibody, ece1.L antibody, Za10_0551 antibody, Arch_0474 antibody, Closa_0961 antibody, Odosp_0578 antibody, Bacsa_1787 antibody, Weevi_2017 antibody, Fluta_3444 antibody, Sphch_2390 antibody, ece1 antibody

Background: Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Synonyms: ECE 1 | ECE1 | ECE-1 | ECE | P42892

Gene ID: 1889

UniProt: P42892

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling