PHC3 antibody (C-Term)

Catalog No. ABIN5517248

Product Details anti-PHC3 Antibody

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHC3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LSRWNRKPDN QSLGHRGRRP SGPDGAAREH ILRQLPITYP SAEEDLASHE

Characteristics: This is a rabbit polyclonal antibody against PHC3. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PHC3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PHC3

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Alternative Name: PHC3 (PHC3 Products)

Synonyms: EDR3 antibody, HPH3 antibody, E030046K01Rik antibody, Edr3 antibody, Hph3 antibody, polyhomeotic homolog 3 antibody, polyhomeotic-like 3 (Drosophila) antibody, Phc3 antibody, PHC3 antibody

Background: PHC3 is a component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Alias Symbols: PHC3, EDR3, PH3,

Protein Interaction Partner: OGT, UBC, EED, RNF2, BMI1, SOX2, ALB, CBX2, PHC3, CBX8, CBX6, SCMH1, CBX4, PCGF2, SCML1, RING1, PHC2, PHC1, SUMO2,

Protein Size: 983

Gene ID: 80012

NCBI Accession: XP_005247847

UniProt: Q8NDX5