0710008C12Rik antibody, Fbxo37 antibody, RGD1306444 antibody, fbl15 antibody, fbxo37 antibody, FBXO37 antibody, Fbl15 antibody, JET antibody, PSD antibody, F4I10.140 antibody, F4I10_140 antibody, SLOW MOTION antibody, fbxl15 antibody, zgc:85882 antibody, F-box and leucine-rich repeat protein 15 antibody, F-box and leucine-rich repeat protein 15 L homeolog antibody, F-box and leucine rich repeat protein 15 antibody, F-box family protein antibody, F-box only protein 37 antibody, Fbxl15 antibody, fbxl15.L antibody, FBXL15 antibody, fbxl15 antibody, SLOMO antibody, fbx37 antibody
Background
FBXL15 is a substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance and also mediates ubiquitination of SMURF2 and WWP2.