FBXL15 antibody (N-Term)

Catalog No. ABIN5517039

Product Details anti-FBXL15 Antibody

Target: FBXL15 (F-Box and Leucine-Rich Repeat Protein 15 (FBXL15))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rabbit, Rat, Cow, Dog, Goat, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL15 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPMEPSGGEQ EPGAVRFLDL PWEDVLLPHV LNRVPLRQLL RLQRVSRAFR

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against FBXL15. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human FBXL15

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL15

Target: FBXL15 (F-Box and Leucine-Rich Repeat Protein 15 (FBXL15))

Alternative Name: FBXL15 (FBXL15 Products)

Synonyms: 0710008C12Rik antibody, Fbxo37 antibody, RGD1306444 antibody, fbl15 antibody, fbxo37 antibody, FBXO37 antibody, Fbl15 antibody, JET antibody, PSD antibody, F4I10.140 antibody, F4I10_140 antibody, SLOW MOTION antibody, fbxl15 antibody, zgc:85882 antibody, F-box and leucine-rich repeat protein 15 antibody, F-box and leucine-rich repeat protein 15 L homeolog antibody, F-box and leucine rich repeat protein 15 antibody, F-box family protein antibody, F-box only protein 37 antibody, Fbxl15 antibody, fbxl15.L antibody, FBXL15 antibody, fbxl15 antibody, SLOMO antibody, fbx37 antibody

Background: FBXL15 is a substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance and also mediates ubiquitination of SMURF2 and WWP2.

Alias Symbols: FBXO37, Fbl15, JET, PSD

Protein Interaction Partner: HNRNPD, SKP1, ITCH, SMURF2, HECW2, SMURF1, NEDD4L, HECW1, WWP2, WWP1, RBX1, CUL1, NEDD4, HSP90AA1, COPS6, UBC,

Protein Size: 300

Gene ID: 79176

NCBI Accession: NM_024326, NP_077302

UniProt: Q9H469