CPSQ4 antibody, SPG51 antibody, RGD1562199 antibody, 2310033A20Rik antibody, 9930028M04Rik antibody, AV087807 antibody, adaptor related protein complex 4 epsilon 1 subunit antibody, adaptor-related protein complex 4, epsilon 1 subunit antibody, adaptor-related protein complex AP-4, epsilon 1 antibody, AP4E1 antibody, Ap4e1 antibody
Background
This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.