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MAPK8IP1 antibody (N-Term)
MAPK8IP1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MAPK8IP1 Antibody
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Target
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MAPK8IP1
(Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
Binding Specificity
All epitopes for MAPK8IP1 antibodies
N-Term
Reactivity
All reactivities for MAPK8IP1 antibodies
Human
Host
All hosts for MAPK8IP1 antibodies
Rabbit
Clonality
All clonalities for MAPK8IP1 antibodies
Polyclonal
Conjugate
All conjugates for MAPK8IP1 antibodies
This MAPK8IP1 antibody is un-conjugated
Application
All applications for MAPK8IP1 antibodies
Western Blotting (WB)
Sequence
GSGDTYRPKR PTTLNLFPQV PRSQDTLNNN SLGKKHSWQD RVSRSSSPLK
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human MAPK8IP1
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Discover our top product MAPK8IP1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 29 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for MAPK8IP1
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Target
MAPK8IP1
(Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
Alternative Name
MAPK8IP1 (MAPK8IP1 Products )
Synonyms
IB1 antibody, JIP-1 antibody, Jip1 antibody, Prkm8ip antibody, Skip antibody, mjip-2a antibody, JIP1 antibody, Jip-1 antibody, Mapk8ip antibody, PRKM8IP antibody, mitogen-activated protein kinase 8 interacting protein 1 antibody, MAPK8IP1 antibody, Mapk8ip1 antibody
Background
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. Alias Symbols: IB1, JIP1, JIP-1, PRKM8IP Protein Size: 711
Gene ID
9479
NCBI Accession
NM_005456 , NP_005447
UniProt
Q9UQF2
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