INCENP antibody (C-Term)

Catalog No. ABIN5516066

Product Details anti-INCENP Antibody

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INCENP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RELEEKKKKE EQQRLAERQL QEEQEKKAKE AAGASKALNV TVDVQSPACT

Predicted Reactivity: Horse: 85%, Human: 100%, Mouse: 86%, Pig: 92%, Rabbit: 92%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against INCENP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human INCENP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for INCENP

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Alternative Name: INCENP (INCENP Products)

Synonyms: INCENP antibody, LOC572121 antibody, 2700067E22Rik antibody, AU019509 antibody, C130081E20 antibody, C77457 antibody, XL-INCENP antibody, incenp antibody, incenp-a antibody, incenp-b antibody, xINC antibody, xIncenp antibody, xl-incenp antibody, inner centromere protein antibody, inner centromere protein S homeolog antibody, inner centromere protein L homeolog antibody, INCENP antibody, Incenp antibody, incenp.S antibody, incenp antibody, incenp.L antibody

Background: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA, CENPB, CENPC1, and CENPD. The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle. These include CENPE, MCAK, KID, cytoplasmic dynein, CliPs, and CENPF/mitosin. The inner centromere proteins (INCENPs), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis

Alias Symbols: INCENP,

Protein Interaction Partner: FLOT1, AURKB, HECW2, AURKC, AURKA, UBC, CDCA8, BIRC5, CBX5, HIST2H3C, SIRT7, Incenp, TUBA1A, EVI5, H2AFZ, SGOL1,

Protein Size: 918

Gene ID: 3619

NCBI Accession: NP_064623

UniProt: Q9NQS7

Pathways: Cell Division Cycle