CRYBB1 antibody (Middle Region)

Catalog No. ABIN5515282

Product Details anti-CRYBB1 Antibody

Target: CRYBB1 (Crystallin, beta B1 (CRYBB1))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYBB1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SIIVSAGPWV AFEQSNFRGE MFILEKGEYP RWNTWSSSYR SDRLMSFRPI

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against CRYBB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human CRYBB1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRYBB1

Target: CRYBB1 (Crystallin, beta B1 (CRYBB1))

Alternative Name: CRYBB1 (CRYBB1 Products)

Synonyms: zgc:92706 antibody, CRYBB1 antibody, catcn3 antibody, Crybb1 antibody, CATCN3 antibody, CTRCT17 antibody, 3110006K12Rik antibody, BB1CRY antibody, CRYB1 antibody, CRYB11 antibody, crystallin, beta B1 antibody, crystallin beta B1 S homeolog antibody, crystallin beta B1 antibody, crybb1 antibody, crybb1.S antibody, CRYBB1 antibody, Crybb1 antibody

Background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3.

Alias Symbols: CATCN3

Protein Interaction Partner: CRYBA1, TERF2IP, TERF1, CRYBB1, ABCC8,

Protein Size: 252

Gene ID: 1414

NCBI Accession: NM_001887, NP_001878

UniProt: P53674