RBM25 antibody (Middle Region)
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- Target See all RBM25 Antibodies
- RBM25 (RNA Binding Motif Protein 25 (RBM25))
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Binding Specificity
- Middle Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RBM25 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- DRDRTKERDR DRDRERDRDR DRERSSDRNK DRSRSREKSR DRERERERER
- Purification
- Affinity purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human RBM25
- Top Product
- Discover our top product RBM25 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- RBM25 (RNA Binding Motif Protein 25 (RBM25))
- Alternative Name
- RBM25 (RBM25 Products)
- Synonyms
- fi03e10 antibody, zgc:56208 antibody, wu:fi03e10 antibody, si:ch211-105d18.5 antibody, rnpc7 antibody, s164 antibody, NET52 antibody, RED120 antibody, RNPC7 antibody, S164 antibody, Snu71 antibody, fSAP94 antibody, 2600011C06Rik antibody, 2610015J01Rik antibody, A130095G20Rik antibody, AI159652 antibody, AL023075 antibody, AU043498 antibody, RNA binding motif protein 25b antibody, RNA binding motif protein 25 antibody, RNA binding motif protein 25 S homeolog antibody, putative rna binding motif protein 25 antibody, rbm25b antibody, Rbm25 antibody, rbm25.S antibody, rbm25 antibody, RBM25 antibody, Smp_078610 antibody
- Background
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RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
Alias Symbols: S164, NET52, RNPC7, Snu71, RED120, fSAP94
Protein Size: 843 - Gene ID
- 58517
- NCBI Accession
- NM_021239, NP_067062
- UniProt
- P49756
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