PEBB antibody (N-Term)
PEBB
Reactivity: Mouse, Rabbit, Rat, Cow, Dog, Guinea Pig, Horse, Human
WB
Host: Rabbit
Polyclonal
unconjugated
1 image
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- Target See all PEBB products
- PEBB (Phycoerythrobilin:ferredoxin Oxidoreductase (PEBB))
- Binding Specificity
- N-Term
- Reactivity
- Mouse, Rabbit, Rat, Cow, Dog, Guinea Pig, Horse, Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Sequence
- CRDGRSEIAF VATGTNLSLQ FFPASWQGEQ RQTPSREYVD LEREAGKVYL
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against PEBB. It was validated on Western Blot.
- Purification
- Affinity purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human PEBB
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PEBB (Phycoerythrobilin:ferredoxin Oxidoreductase (PEBB))
- Alternative Name
- PEBB (PEBB Products)
- Background
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The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CBFB,
Protein Interaction Partner: vif, CUL5, UBC, RAB2A, MYC, nef, APOBEC3G, RUNX1, ELAVL1, KMT2A, COPRS, RUNX3, MYOD1, CHGB, CBFA2T2, RUNX2, CBFB, C1QBP,
Protein Size: 182 - Gene ID
- 865
- UniProt
- Q13951
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