Glucosylceramidase antibody (N-Term)
GLCM
Reactivity: Mouse, Pig, Rabbit, Cow, Rat, Dog, Guinea Pig, Horse, Human
WB
Host: Rabbit
Polyclonal
unconjugated
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- Target See all Glucosylceramidase (GLCM) products
- Glucosylceramidase (GLCM)
- Binding Specificity
- N-Term
- Reactivity
- Mouse, Pig, Rabbit, Cow, Rat, Dog, Guinea Pig, Horse, Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Sequence
- FSSPSREECP KPLSRVSIMA GSLTGLLLLQ AVSWASGARP CIPKSFGYSS
- Predicted Reactivity
- Cow: 75%, Dog: 75%, Guinea Pig: 75%, Horse: 75%, Human: 100%, Mouse: 75%, Pig: 79%, Rabbit: 75%, Rat: 75%
- Characteristics
- This is a rabbit polyclonal antibody against GLCM. It was validated on Western Blot.
- Purification
- Affinity purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human GLCM
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Glucosylceramidase (GLCM)
- Alternative Name
- GLCM (GLCM Products)
- Background
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This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
Alias Symbols: GBA, GC, GLUC,
Protein Interaction Partner: NUDCD1, UBC, ITCH, ATP6V1B1, SNCA, FBXO6, TCP1, CBL, NEDD4, PARK2, HSP90AA1, HSPA4, PSAP,
Protein Size: 536 - Gene ID
- 2629
- NCBI Accession
- XP_006711333
- UniProt
- P04062
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