LARP6 antibody (AA 1-491)

Catalog No. ABIN527496

Product Details anti-LARP6 Antibody

Target: LARP6 (La Ribonucleoprotein Domain Family, Member 6 (LARP6))

Binding Specificity: AA 1-491

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This LARP6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: Mouse polyclonal antibody raised against a full-length human LARP6 protein.

Sequence: MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: LARP6 (NP_060827, 1 a.a. ~ 491 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-LARP6 antibody (ABIN527496)

Blackstock, Higashi, Sukhanov, Shai, Stefanovic, Tabony, Yoshida, Delafontaine: "Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA." in: The Journal of biological chemistry, Vol. 289, Issue 11, pp. 7264-74, (2014) (PubMed).

Wang, Stefanovic: "Role of LARP6 and nonmuscle myosin in partitioning of collagen mRNAs to the ER membrane." in: PLoS ONE, Vol. 9, Issue 10, pp. e108870, (2014) (PubMed).

Manojlovic, Blackmon, Stefanovic: "Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis." in: PLoS ONE, Vol. 8, Issue 6, pp. e65897, (2013) (PubMed).

Vukmirovic, Manojlovic, Stefanovic: "Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs." in: Molecular and cellular biology, Vol. 33, Issue 19, pp. 3893-906, (2013) (PubMed).

Manojlovic, Stefanovic: "A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs." in: RNA (New York, N.Y.), Vol. 18, Issue 2, pp. 321-34, (2012) (PubMed).

Challa, Stefanovic: "A novel role of vimentin filaments: binding and stabilization of collagen mRNAs." in: Molecular and cellular biology, Vol. 31, Issue 18, pp. 3773-89, (2011) (PubMed).

Cai, Fritz, Stefanovic, Stefanovic: "Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen." in: Journal of molecular biology, Vol. 395, Issue 2, pp. 309-26, (2010) (PubMed).

Cai, Fritz, Stefanovic, Stefanovic: "Nonmuscle myosin-dependent synthesis of type I collagen." in: Journal of molecular biology, Vol. 401, Issue 4, pp. 564-78, (2010) (PubMed).

Target Details for LARP6

Target: LARP6 (La Ribonucleoprotein Domain Family, Member 6 (LARP6))

Alternative Name: LARP6 (LARP6 Products)

Synonyms: im:7142825 antibody, wu:fa55b04 antibody, ACHN antibody, 5430431G03Rik antibody, AI552438 antibody, Achn antibody, RGD1308414 antibody, La ribonucleoprotein domain family, member 6b antibody, La ribonucleoprotein domain family member 6 antibody, La ribonucleoprotein domain family, member 6 antibody, larp6b antibody, LARP6 antibody, Larp6 antibody

Background: Full Gene Name: La ribonucleoprotein domain family, member 6
Synonyms: ACHN,FLJ11196

Gene ID: 55323

NCBI Accession: NM_018357