TREX1 antibody (AA 1-369)

Catalog No. ABIN524703

Product Details anti-TREX1 Antibody

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Binding Specificity: AA 1-369

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TREX1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit polyclonal antibody raised against a full-length human TREX1 protein.

Sequence: MGPGARRQGR IVQGRPEMCF CPPPTPLPPL RILTLGTHTP TPCSSPGSAA GTYPTMGSQA LPPGPMQTLI FFDMEATGLP FSQPKVTELC LLAVHRCALE SPPTSQGPPP TVPPPPRVVD KLSLCVAPGK ACSPAASEIT GLSTAVLAAH GRQCFDDNLA NLLLAFLRRQ PQPWCLVAHN GDRYDFPLLQ AELAMLGLTS ALDGAFCVDS ITALKALERA SSPSEHGPRK SYSLGSIYTR LYGQSPPDSH TAEGDVLALL SICQWRPQAL LRWVDAHARP FGTIRPMYGV TASARTKPRP SAVTTTAHLA TTRNTSPSLG ESRGTKDLPP VKDPGALSRE GLLAPLGLLA ILTLAVATLY GLSLATPGE

Cross-Reactivity: Human, Mouse

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: TREX1 (NP_057465.1, 1 a.a. ~ 369 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-TREX1 antibody (ABIN524703)

Tomicic, Aasland, Nikolova, Kaina, Christmann: "Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs." in: Biochimica et biophysica acta, Vol. 1833, Issue 8, pp. 1832-43, (2013) (PubMed).

Christmann, Tomicic, Aasland, Berdelle, Kaina: "Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage." in: Nucleic acids research, Vol. 38, Issue 19, pp. 6418-32, (2010) (PubMed).

Target Details for TREX1

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Alternative Name: TREX1 (TREX1 Products)

Background: Full Gene Name: three prime repair exonuclease 1
Synonyms: AGS1,AGS5,CRV,DKFZp434J0310,DRN3,HERNS

Gene ID: 11277

NCBI Accession: NM_016381

Pathways: Apoptosis