AIM2 antibody (AA 1-343)

Catalog No. ABIN522906

Product Details anti-AIM2 Antibody

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Binding Specificity: AA 1-343

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This AIM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: Mouse polyclonal antibody raised against a full-length human AIM2 protein.

Sequence: MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL NIIRKAGETP KINTLQTQPL GTIVNGLFVV QKVTEKKKNI LFDLSDNTGK MEVLGVRNED TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: AIM2 (NP_004824, 1 a.a. ~ 343 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-AIM2 antibody (ABIN522906)

Ansari, Singh, Dutta, Veettil, Dutta, Chikoti, Lu, Everly, Chandran: "Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells." in: Journal of virology, Vol. 87, Issue 15, pp. 8606-23, (2013) (PubMed).

Lee, Li, Gretz, Gebert, Dihlmann: "Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers." in: Oncogene, Vol. 31, Issue 10, pp. 1242-53, (2012) (PubMed).

Wang, Hsu, Chen, Liang, Chen, Ojcius, Tsang, Hsueh, Wu, Chang: "Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 11, pp. 1230-44, (2012) (PubMed).

Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." in: Nature, Vol. 458, Issue 7237, pp. 509-13, (2009) (PubMed).

Target Details for AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Alternative Name: AIM2 (AIM2 Products)

Synonyms: AIM2 antibody, PYHIN4 antibody, Gm1313 antibody, Ifi210 antibody, absent in melanoma 2 antibody, AIM2 antibody, Aim2 antibody

Background: Full Gene Name: absent in melanoma 2
Synonyms: PYHIN4

Gene ID: 9447

NCBI Accession: NM_004833

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome