EIF2AK2 antibody (AA 1-100)

Catalog No. ABIN519273

Product Details anti-EIF2AK2 Antibody

Target: EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Binding Specificity: AA 1-100

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EIF2AK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a partial recombinant EIF2AK2.

Sequence: MAGDLSAGFF MEELNTYRQK QGVVLKYQEL PNSGPPHDRR FTFQVIIDGR EFPEGEGRSK KEAKNAAAKL AVEILNKEKK AVSPLLLTTT NSSEGLSMGN

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: EIF2AK2 (NP_002750, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1D11

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-EIF2AK2 antibody (ABIN519273)

Liu, Bennett, Cheng, Byrne, Reinhard, May: "PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells." in: Blood, Vol. 121, Issue 17, pp. 3364-74, (2013) (PubMed).

Cheng, Bennett, Liu, Byrne, Stratford May: "PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis." in: Blood cancer journal, Vol. 3, pp. e144, (2013) (PubMed).

Bennett, Carruthers, Hui, Kerney, Liu, May: "Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin." in: PLoS ONE, Vol. 7, Issue 9, pp. e46040, (2012) (PubMed).

Target Details for EIF2AK2

Target: EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Alternative Name: EIF2AK2 (EIF2AK2 Products)

Background: Full Gene Name: eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms: EIF2AK1,MGC126524,PKR,PRKR

Gene ID: 5610

NCBI Accession: NM_002759

Pathways: DNA Damage Repair, ER-Nucleus Signaling, Hepatitis C