NBR1 antibody (AA 2-96)

Catalog No. ABIN517601

Product Details anti-NBR1 Antibody

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Binding Specificity: AA 2-96

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NBR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse monoclonal antibody raised against a partial recombinant NBR1.

Sequence: EPQVTLNVTF KNEIQSFLVS DPENTTWADI EAMVKVSFDL NTIQIKYLDE ENEEVSINSQ GEYEEALKMA VKQGNQLQMQ VHEGHHVVDE APPPV

Cross-Reactivity: Human, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: NBR1 (NP_005890, 2 a.a. ~ 96 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 6B11

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-NBR1 antibody (ABIN517601)

Jiang, Hara-Kuge, Yamashita, Fujiki: "Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, Issue 1, pp. 36-49, (2015) (PubMed).

Dowdle, Nyfeler, Nagel, Elling, Liu, Triantafellow, Menon, Wang, Honda, Pardee, Cantwell, Luu, Cornella-Taracido, Harrington, Fekkes, Lei, Fang, Digan, Burdick, Powers, Helliwell, DAquin, Bastien et al.: "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. ..." in: Nature cell biology, Vol. 16, Issue 11, pp. 1069-79, (2014) (PubMed).

Rué, López-Soop, Gelpi, Martínez-Vicente, Alberch, Pérez-Navarro: "Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease." in: Neurobiology of disease, Vol. 52, pp. 219-28, (2013) (PubMed).

Deosaran, Larsen, Hua, Sargent, Wang, Kim, Lamark, Jauregui, Law, Lippincott-Schwartz, Brech, Johansen, Kim: "NBR1 acts as an autophagy receptor for peroxisomes." in: Journal of cell science, Vol. 126, Issue Pt 4, pp. 939-52, (2013) (PubMed).

Wong, Bejarano, Rakshit, Lee, Hanson, Zaarur, Phillips, Sherman, Cuervo: "Molecular determinants of selective clearance of protein inclusions by autophagy." in: Nature communications, Vol. 3, pp. 1240, (2012) (PubMed).

Mardakheh, Auciello, Dafforn, Rappoport, Heath: "Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation." in: Molecular and cellular biology, Vol. 30, Issue 24, pp. 5672-85, (2010) (PubMed).

Mardakheh, Yekezare, Machesky, Heath: "Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling." in: The Journal of cell biology, Vol. 187, Issue 2, pp. 265-77, (2009) (PubMed).

Target Details for NBR1

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Alternative Name: NBR1 (NBR1 Products)

Synonyms: fa99f08 antibody, wu:fa99f08 antibody, MGC69008 antibody, NBR1 antibody, 1A1-3B antibody, M17S2 antibody, mKIAA0049 antibody, Ca125 antibody, RGD1311421 antibody, neighbor of brca1 gene 1a antibody, neighbor of BRCA1 gene 1 L homeolog antibody, NBR1, autophagy cargo receptor antibody, neighbor of Brca1 gene 1 antibody, nbr1a antibody, nbr1.L antibody, NBR1 antibody, Nbr1 antibody

Background: Full Gene Name: neighbor of BRCA1 gene 1
Synonyms: 1A1-3B,KIAA0049,M17S2,MIG19

Gene ID: 4077

NCBI Accession: NM_005899

Pathways: Autophagy