CYP3A4
Reactivity: Human
WB, IHC, ICC, IP
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Buffer
In 1x PBS, pH 7.4
Handling Advice
Aliquot to avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Wiegand, Hewitt, Merk, Reisinger: "Dermal xenobiotic metabolism: a comparison between native human skin, four in vitro skin test systems and a liver system." in: Skin pharmacology and physiology, Vol. 27, Issue 5, pp. 263-75, (2014) (PubMed).
Fahrmayr, König, Auge, Mieth, Münch, Segrestaa, Pfeifer, Treiber, Fromm: "Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line." in: British journal of pharmacology, Vol. 169, Issue 1, pp. 21-33, (2013) (PubMed).
Yamashita, Honda, Nio, Nakamoto, Yamashita, Takamura, Tani, Zen, Kaneko: "Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation." in: Cancer research, Vol. 70, Issue 11, pp. 4687-97, (2010) (PubMed).
Target
CYP3A4
(Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))