MHC Class II HLA-DP/DQ/DR antibody

Catalog No. ABIN5067814

Product Details anti-MHC Class II HLA-DP/DQ/DR Antibody

Target: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MHC Class II HLA-DP/DQ/DR antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purpose: Anti-HLA-DR,DP,DQ Unconjugated Antibody

Characteristics: The clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS expressed HLA-DR only.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: Priess human B cell line

Clone: IVA12

Isotype: IgG1, kappa

Application Details

Application Notes: Each lot of this antibody has been pre-titrated and tested by flow cytometric analysis of human PBMCs such that 0.5µg is sufficient for staining 1 million cells in a 100µl staining volume or 100µl of whole blood. It is recommended to titrate antibody reactivity empirically for optimal performance.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for MHC Class II HLA-DP/DQ/DR

Target: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Alternative Name: HLA-DR, DP, DQ (HLA-DP/DQ/DR Products)

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response