SCNN1B antibody (AA 617-638) (PE)
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- Target See all SCNN1B Antibodies
- SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))
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Binding Specificity
- AA 617-638
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Reactivity
- Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This SCNN1B antibody is conjugated to PE
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- Detects ~87 kDa.
- Cross-Reactivity
- Mouse
- Purification
- Protein G Purified
- Immunogen
- Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638)
- Clone
- 7B8
- Isotype
- IgG1
- Top Product
- Discover our top product SCNN1B Primary Antibody
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- Application Notes
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- WB (1:1000)
- IHC (1:150)
- optimal dilutions for assays should be determined by the user.
- Comment
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A 1:1000 dilution of ABIN5066891 was sufficient for detection of ENaC beta in 15 μg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Conjugated antibodies should be stored at 4°C
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- Target
- SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))
- Alternative Name
- ENaC beta (SCNN1B Products)
- Synonyms
- BESC1 antibody, ENaCb antibody, ENaCbeta antibody, SCNEB antibody, RNENACB antibody, besc1 antibody, betaxENaC antibody, enacb antibody, enacbeta antibody, scnn1b antibody, beta-ENaC antibody, scneb antibody, SCNN1B antibody, BETA-ENAC antibody, sodium channel epithelial 1 beta subunit antibody, sodium channel, non voltage gated 1 beta subunit L homeolog antibody, sodium channel, non voltage gated 1 beta subunit antibody, sodium channel, nonvoltage-gated 1 beta antibody, sodium channel, non voltage gated 1 beta subunit S homeolog antibody, SCNN1B antibody, Scnn1b antibody, scnn1b.L antibody, scnn1b antibody, scnn1b.S antibody
- Background
- The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
- Gene ID
- 24767
- NCBI Accession
- NP_036780
- UniProt
- P37090
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