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FNIP1 antibody

FNIP1 Reactivity: Human WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5066839
  • Target See all FNIP1 Antibodies
    FNIP1 (Folliculin Interacting Protein 1 (FNIP1))
    Reactivity
    • 18
    • 1
    • 1
    Human
    Host
    • 17
    • 1
    Rabbit
    Clonality
    • 18
    Polyclonal
    Conjugate
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FNIP1 antibody is un-conjugated
    Application
    • 12
    • 11
    • 11
    • 10
    • 6
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.,Detects ~130 kDa.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Peptide Affinity Purified
    Immunogen
    Synthetic peptide from the mid-protein of Human FNIP1
    Isotype
    IgG
  • Application Notes
    • WB (1:1000)
    • ICC/IF (1:100)
    • IHC (1:50)
    • optimal dilutions for assays should be determined by the user.
    Comment

    A 1:1000 dilution of ABIN5066839 was sufficient for detection of FNIP1 in 15 μg of mouse kidney cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C
  • Target
    FNIP1 (Folliculin Interacting Protein 1 (FNIP1))
    Alternative Name
    FNIP1 (FNIP1 Products)
    Synonyms
    FNIP1 antibody, DKFZp468P0310 antibody, A730024A03Rik antibody, AI838773 antibody, AW557298 antibody, folliculin interacting protein 1 antibody, FNIP1 antibody, fnip1 antibody, Fnip1 antibody
    Background
    Folliculin-interacting protein 1 (FNIP1) is a co-chaperone of HSP90 (1). It Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways and may regulate the phosphorylation of RPS6KB1 (2). FNIP1 is strongly expressed in the heart, liver placenta, muscle, nasal mucosa, salivary gland, and uvula. Elevated levels of FNIP1 have been detected in renal cell carcinoma (RCC) (3).
    Gene ID
    96459
    NCBI Accession
    NP_001008738
    UniProt
    Q8TF40
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