Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Vangl1 antibody (AA 148-400)

Vangl1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5027627
  • Target See all Vangl1 Antibodies
    Vangl1 (Vang-Like 1 (Vangl1))
    Binding Specificity
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 148-400
    Reactivity
    • 25
    • 13
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 24
    • 2
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Vangl1 antibody is un-conjugated
    Application
    • 19
    • 8
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Protein A Chromatography
    Immunogen
    A partial length recombinant Vang like-1 protein (amino acids 148-400) was used as the immunogen for this antibody.
    Isotype
    IgG
    Top Product
    Discover our top product Vangl1 Primary Antibody
  • Application Notes
    WB: 2-4 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS containing 0.05 % BSA, PH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • Target
    Vangl1 (Vang-Like 1 (Vangl1))
    Alternative Name
    Vang like-1 (Vangl1 Products)
    Synonyms
    stb2 antibody, Kitenin antibody, Lpp2 antibody, Stb2 antibody, Stbm antibody, KITENIN antibody, LPP2 antibody, STB2 antibody, STBM2 antibody, VANGL planar cell polarity protein 1 antibody, vang-like 1 (van gogh, Drosophila) antibody, Vangl1 antibody, vangl1 antibody, VANGL1 antibody
    Background
    Vangl1 (VANGL planar cell polarity protein 1) is an integral membrane protein that belongs to the tetraspanin family having four transmembrane domains. Tetraspanins form large multimolecular complexes on the cell membrane and are involved in cellular signaling, membrane formation, and migration. Vangl1 is expressed at the plasma membrane of different tissues and play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. It is a highly conserved and have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the vangl1 gene cause NTDs (neural tube defects). Ser/Thr phosphorylation of Vangl1 serves as an effector mediating the ITF healing response of the intestinal mucosa. In colon carcinoma cell lines, Vangl1 interacts with KAI1 (CD82) tumor metastasis suppressor. Vangl1 overexpression increases motility and metastasis, whereas its inhibition decreases motility and metastasis of colon cancer confirming migratory phenotype for Vangl1 in colonic epithelial cells.
    Molecular Weight
    62 kDa
    Gene ID
    81839
    UniProt
    Q8TAA9
    Pathways
    WNT Signaling
You are here:
Support