RAX antibody (AA 100-313)

Catalog No. ABIN5027505

Product Details anti-RAX Antibody

Target: RAX (Retina and Anterior Neural Fold Homeobox (RAX))

Binding Specificity: AA 100-313

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAX antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant RAX protein (amino acids 100-313) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for RAX

Target: RAX (Retina and Anterior Neural Fold Homeobox (RAX))

Alternative Name: RAX (RAX Products)

Synonyms: MCOP3 antibody, RX antibody, 7530406A22Rik antibody, E130303K03Rik antibody, Rx antibody, ey-1 antibody, ey1 antibody, RAX antibody, rx antibody, rx1 antibody, Rx2A antibody, Xrax antibody, Xrx1 antibody, rax antibody, CG10052 antibody, DRx antibody, Dmel\\CG10052 antibody, Drx antibody, E97 antibody, PPH17 antibody, W60 antibody, bk50 antibody, drx antibody, wom antibody, Xrx2 antibody, rax-a antibody, rax1 antibody, rx1a antibody, rx2a antibody, retina and anterior neural fold homeobox antibody, Retinal Homeobox antibody, retina and anterior neural fold homeobox L homeolog antibody, retina and anterior neural fold homeobox S homeolog antibody, RAX antibody, Rax antibody, rax antibody, Rx antibody, rax.L antibody, rax.S antibody

Background: RAX or PRKRA (retina and anterior neural fold homeobox) is a homeobox-containing transcription factor. It plays an important role in eye development by regulating the initial specification of retinal cells. In the absence of double-stranded RNA, RAX activates EIF2AK2/PKR, so as to phosphorylate EIF2S1/EFI2-alpha leading to inhibition of translation and induction of apoptosis. RAX has been reported to be essential for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia and coloboma. RAX is expressed in blood, bone, brain, spleen and adipose tissues.

Molecular Weight: 30 kDa

Gene ID: 8575

UniProt: O75569

Pathways: Regulatory RNA Pathways