ZFYVE27 antibody (AA 341-411) (AbBy Fluor® 750)
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- Target See all ZFYVE27 Antibodies
- ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))
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Binding Specificity
- AA 341-411
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ZFYVE27 antibody is conjugated to AbBy Fluor® 750
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Dog,Cow,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human ZFYVE27
- Isotype
- IgG
- Top Product
- Discover our top product ZFYVE27 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))
- Alternative Name
- ZFYVE27 (ZFYVE27 Products)
- Synonyms
- ZFYVE27 antibody, MGC130947 antibody, spg33 antibody, im:7137347 antibody, zgc:153156 antibody, PROTRUDIN antibody, RP11-459F3.2 antibody, SPG33 antibody, 2210011N02Rik antibody, 9530077C24Rik antibody, AI426636 antibody, AI593546 antibody, AI835681 antibody, zinc finger FYVE-type containing 27 antibody, zinc finger FYVE domain containing 27 L homeolog antibody, zinc finger FYVE domain containing 27 antibody, zinc finger, FYVE domain containing 27 antibody, ZFYVE27 antibody, zfyve27.L antibody, zfyve27 antibody, Zfyve27 antibody
- Background
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Synonyms: Protrudin, RP11 459F3.2, SPG33, ZFY27_HUMAN, ZFYVE27, zinc finger FYVE domain containing 27, Zinc finger FYVE domain containing protein 27, Zinc finger FYVE domain-containing protein 27.
Background: Zinc finger FYVE domain-containing protein 27 (ZFYVE27), also known as SPG33, is a 411 amino acid member of the FYVE-finger family of proteins. The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, and a majority of these proteins serve as regulators of endocytic membrane trafficking. ZFYVE27, a multi-pass membrane protein, is an endosomal protein that binds to Spastin, a protein that is primarily involved in microtubule dynamics and severing, vesicular trafficking and endosomal trafficking. Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), a neurodegenerative disorder, characterized by progressive paralysis of the legs, which is caused by impaired axonal transport. Five isoforms of ZFYVE27 exist as a result of alternative splicing events.
- Gene ID
- 118813
- UniProt
- Q5T4F4
- Pathways
- Neurotrophin Signaling Pathway
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