TOM1L1 antibody (AA 1-100) (AbBy Fluor® 750)
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- Target See all TOM1L1 Antibodies
- TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))
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Binding Specificity
- AA 1-100
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TOM1L1 antibody is conjugated to AbBy Fluor® 750
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Cow,Sheep,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TOM1L1
- Isotype
- IgG
- Top Product
- Discover our top product TOM1L1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))
- Alternative Name
- TOM1L1 (TOM1L1 Products)
- Synonyms
- MGC52738 antibody, srcasm antibody, TOM1L1 antibody, OK/KNS-CL.3 antibody, SRCASM antibody, RGD1562626 antibody, Srcasm antibody, 2310045L10Rik antibody, C80573 antibody, target of myb1 like 1 membrane trafficking protein L homeolog antibody, target of myb1 like 1 membrane trafficking protein antibody, target of myb1-like 1 (chicken) antibody, tom1l1.L antibody, TOM1L1 antibody, tom1l1 antibody, Tom1l1 antibody
- Background
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Synonyms: OK/KNS CL.3, Src activating and signaling molecule, Src activating and signaling molecule protein, Src-activating and signaling molecule protein, SRCASM, Target of Myb like protein 1, Target of Myb-like protein 1, Target of myb1 chicken homolog like 1, Target of myb1 chicken like 1, Target of myb1 like 1, TM1L1_HUMAN, TOM1 L1, TOM1 like protein 1, TOM1-like protein 1, TOM1L1, TOM1L1 protein.
Background: Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.
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