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ATL1 antibody (AA 201-300) (AbBy Fluor® 750)

ATL1 Reactivity: Mouse, Rat WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 750
Catalog No. ABIN5010920
  • Target See all ATL1 Antibodies
    ATL1 (Atlastin GTPase 1 (ATL1))
    Binding Specificity
    • 14
    • 10
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reactivity
    • 34
    • 18
    • 18
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 46
    • 2
    Rabbit
    Clonality
    • 46
    • 2
    Polyclonal
    Conjugate
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATL1 antibody is conjugated to AbBy Fluor® 750
    Application
    • 37
    • 22
    • 12
    • 12
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SPG3A/Atlastin
    Isotype
    IgG
    Top Product
    Discover our top product ATL1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    ATL1 (Atlastin GTPase 1 (ATL1))
    Alternative Name
    SPG3A/Atlastin (ATL1 Products)
    Synonyms
    ATL1 antibody, SPG3A antibody, fj46c01 antibody, wu:fj46c01 antibody, spg3a antibody, MGC146251 antibody, AD-FSP antibody, FSP1 antibody, GBP3 antibody, HSN1D antibody, SPG3 antibody, atlastin1 antibody, 4930435M24Rik antibody, Adfsp antibody, Fsp1 antibody, Spg3 antibody, Spg3a antibody, atlastin antibody, Atlastin-1 antibody, atlastin GTPase 1 antibody, ATL1 antibody, atl1 antibody, Atl1 antibody
    Background

    Synonyms: AD FSP, atl1, ATLA1_HUMAN, Atlastin GTPase 1, Atlastin-1, Atlastin1, Brain specic GTP binding protein, Brain-specic GTP-binding protein, FSP1, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, Guanylate binding protein 3, hGBP3, HSN1D, Spastic paraplegia 3 protein A, SPG 3A, SPG3, SPG3A.

    Background: Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10 % of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40 %.

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