TREX2 antibody (C-Term)

Catalog No. ABIN501038

Product Details anti-TREX2 Antibody

Target: TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TREX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects TREX2. The antibody will not cross-react with the related protein TREX1.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: TREX2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TREX2

Target: TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))

Alternative Name: TREX2 (Trex2 Products)

Synonyms: RGD1562245 antibody, three prime repair exonuclease 2 antibody, TREX2 antibody, Trex2 antibody

Background: TREX2 is one of two major human 3\' to 5\' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.Synonyms: 3'-5' exonuclease TREX2, Three prime repair exonuclease 2

Gene ID: 11219

UniProt: Q9BQ50