TMEM38B antibody (C-Term)

Catalog No. ABIN500986

Product Details anti-TMEM38B Antibody

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM38B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: TMEM38B antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38B.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for TMEM38B

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Alternative Name: TMEM38B (TMEM38B Products)

Synonyms: zgc:55815 antibody, tricb antibody, tric-b antibody, MGC83592 antibody, DKFZp469C0220 antibody, C9orf87 antibody, D4Ertd89e antibody, OI14 antibody, TRIC-B antibody, TRICB antibody, bA219P18.1 antibody, 1600017F22Rik antibody, AA437809 antibody, AV051057 antibody, mg33b antibody, RGD1305703 antibody, transmembrane protein 38B antibody, transmembrane protein 38B L homeolog antibody, tmem38b antibody, TMEM38B antibody, tmem38b.L antibody, Tmem38b antibody

Background: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.Synonyms: C9orf87, TRIC-B, TRICB, Transmembrane protein 38B, Trimeric intracellular cation channel type B

Gene ID: 55151

NCBI Accession: NP_060582