RAPGEF6 antibody (AA 601-700) (AbBy Fluor® 750)
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- Target See all RAPGEF6 Antibodies
- RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))
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Binding Specificity
- AA 601-700
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RAPGEF6 antibody is conjugated to AbBy Fluor® 750
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human RAGEF2
- Isotype
- IgG
- Top Product
- Discover our top product RAPGEF6 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))
- Alternative Name
- RAGEF2 (RAPGEF6 Products)
- Synonyms
- KIA001LB antibody, PDZ-GEF2 antibody, PDZGEF2 antibody, RA-GEF-2 antibody, RAGEF2 antibody, A530068K01 antibody, AI844632 antibody, BB085664 antibody, C030018K18Rik antibody, Pdzgef2 antibody, Ragef2 antibody, mKIAA4052 antibody, wu:fa12b02 antibody, RAPGEF6 antibody, Rap guanine nucleotide exchange factor 6 antibody, Rap guanine nucleotide exchange factor (GEF) 6 antibody, RAPGEF6 antibody, Rapgef6 antibody, rapgef6 antibody
- Background
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Synonyms: DKFZp667N084, DKFZp686I15116, KIA001LB, PDZ domain containing guanine nucleotide exchange factor GEF 2, PDZ domain containing guanine nucleotide exchange factor 2, PDZ domain containing guanine nucleotide exchange factor I, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ GEF 2, PDZ GEF2, PDZ-GEF2, PDZGEF 2, PDZGEF2, RA GEF 2, RA GEF2, RA-GEF-2, RAGEF 2, Rap guanine nucleotide exchange factor GEF 6, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor 6, RAPGEF6, RPGF6_HUMAN.
Background: RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B.
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