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TIGAR antibody (Center)

TIGAR Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500907
  • Target See all TIGAR Antibodies
    TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
    Binding Specificity
    • 15
    • 12
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 37
    • 33
    • 4
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 57
    • 1
    • 1
    Rabbit
    Clonality
    • 59
    Polyclonal
    Conjugate
    • 24
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TIGAR antibody is un-conjugated
    Application
    • 40
    • 26
    • 13
    • 13
    • 9
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects TIGAR at center.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    TIGAR antibody was raised against a 18 amino acid peptide from near the center of human TIGAR.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
    Alternative Name
    TIGAR (TIGAR Products)
    Synonyms
    AA793651 antibody, AI595337 antibody, C79710 antibody, C85509 antibody, Tigar antibody, Trp53 induced glycolysis repulatory phosphatase antibody, Tigar antibody
    Background
    The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.Synonyms: 6-bisphosphatase TIGAR, C12orf5, Probable fructose-2, TP53-induced glycolysis and apoptosis regulator
    Gene ID
    57103
    NCBI Accession
    NP_065108
    Pathways
    Warburg Effect
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