NPDC1 antibody (AA 75-180) (AbBy Fluor® 680)
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- Target See all NPDC1 Antibodies
- NPDC1 (Neural Proliferation, Differentiation and Control, 1 (NPDC1))
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Binding Specificity
- AA 75-180
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NPDC1 antibody is conjugated to AbBy Fluor® 680
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Mouse
- Predicted Reactivity
- Human,Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human NPDC1
- Isotype
- IgG
- Top Product
- Discover our top product NPDC1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- NPDC1 (Neural Proliferation, Differentiation and Control, 1 (NPDC1))
- Alternative Name
- NPDC1 (NPDC1 Products)
- Synonyms
- AI314472 antibody, NPDC-1 antibody, CAB antibody, CAB- antibody, CAB-1 antibody, CAB1 antibody, neural proliferation, differentiation and control, 1, gene 1 L homeolog antibody, neural proliferation, differentiation and control 1 antibody, neural proliferation, differentiation and control, 1 antibody, npdc1.1.L antibody, Npdc1 antibody, NPDC1 antibody
- Background
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Synonyms: AI314472, CAB1, Neural proliferation dferentiation and control protein 1, NPDC-1, NPDC1, NPDC1_HUMAN.
Background: NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human.
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